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Is glutathione (GSH) effective as an oral supplement?

The efficacy of orally administered glutathione for the improvement of GSH levels in cells and tissues has been controversially discussed and questioned in the professional world for years. This went often together with the recommendation to positively stimulate GSH levels via precursors such as N-acetylcysteine or derivatives such as S-acetylglutathione.

A new clinical study (double-blind, randomized and placebo-controlled) at the Penn State College of Medicine (USA) conducted by internationally renowned scientists has now come to the clear conclusion that the oral intake of GSH significantly increases the body-specific GSH levels. The results of the study can be found here.

The indirect route via GSH-derivatives or precursors – often expensive and not sufficiently proven by conclusive clinical studies – thus seems to have become superfluous, once glutathione is available as a natural and non-chemically modified original molecule in form of a dietary supplement. The bioavailability of GSH via oral administration is now clearly demonstrated by clinical studies.


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